New Drug Approved By FDA (First Generic Drug)

Trandolapril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme.







Verapamil is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels.






The combination of trandolapril and verapamil is used to treat high blood pressure (hypertension).

What is the most important information I should know about trandolapril and verapamil?


Do not use trandolapril and verapamil if you are pregnant. It could harm the unborn baby. Stop using this medication and tell your doctor right away if you become pregnant. Do not use salt substitutes or potassium supplements while taking trandolapril and verapamil, unless your doctor has told you to.


Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. This can lead to very low blood pressure, electrolyte disorders, or kidney failure while you are taking trandolapril and verapamil. Drink plenty of water each day while you are taking this medication.






Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.






What should I discuss with my healthcare provider before taking trandolapril and verapamil?


You should not use this medication if you are allergic to trandolapril (Mavik) or verapamil (Calan, Covera, Isoptin, Verelan), or if you have:


certain heart conditions, especially "sick sinus syndrome" or "AV block" (unless you have a pacemaker);






a heart rhythm disorder;






low blood pressure; or






if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), or ramipril (Altace).






If you have any of these other conditions, you may need a trandolapril and verapamil dose adjustment or special tests:






kidney disease (or if you are on dialysis);






liver disease;






congestive heart failure;






diabetes; or






a nerve-muscle disease such as muscular dystrophy.






 Do not use trandolapril and verapamil if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. Stop using this medication and tell your doctor right away if you become pregnant. Trandolapril and verapamil can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Trandolapril and verapamil can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.


Gurbinder Sharma
CCHR.ORG
Investigator